What Does Science Say About the Best Strains for Creativity?

Research into connections between cannabis and creativity initially indicated cannabinoids might play a significant role in jumpstarting creativity. Consequently, the idea that the best strains for creativity–that is, cannabis strains with moderate to higher levels of cannabinoids–entered the mainstream and stayed there until researchers stumbled upon the astounding power of terpenes to boost imagination and creativity.

About Cannabis Strains, Terpenes, Cannabinoids, and the Entourage Effect

The species of a cannabis plant is determined by its phenotype or the expression of genetic material during the cultivation of the plant. The most well-known cannabis strains are indica and sativa. Both these strains are widely used for recreational and medicinal purposes. For example, sativa strains may help reduce anxiety, enhance creativity, relieve pain and improve appetite. For medicinal purposes, cannabis sativa may be prescribed to people with chronic pain and inflammatory diseases.

Indica strains may help treat insomnia, alleviate anxiety, relax severe muscle spasms and reduce the occurrence of epileptic seizures. The primary difference between indica and sativa strains is that indica has more CBD while sativa contains more THC. Both cannabinoids may offer different health benefits for medical conditions that fail to respond to traditional treatment.

So, what are the best strains for creativity? Indica? Sativa? Or are there lesser-known strains of cannabis that may free your inner muse?

Many studies are finding that it’s not all about the strain for improving creativity. There is yet another cannabis constituent that not only enhances your creativity and problem-solving skills but works to strengthen all therapeutic advantages of cannabis–terpenes.

If you have never read much about terpenes, you’re not alone. An aromatic resin found in all plants, terpenes recently came under scrutiny by cannabis researchers when they discovered it wasn’t cannabinoids alone that increased a person’s creativity. Instead, they found terpenes amplified all the mental and physical benefits–especially creativity–of cannabinoids by creating the entourage effect.

In addition to providing the unique aroma and flavor of cannabis, terpenes support the efficacy of cannabinoids to exert their numerous therapeutic effects. This synergy between terpenes, cannabinoids and other phytochemicals is what creates the entourage effect. In other words, researchers are learning that the power of cannabis to enhance creativity and treat numerous health problems lies predominantly in the presence of terpenes.

So, just how important to improving creativity is cannabis strain? Not much, due to years of cannabis cultivators cross breeding pure sativa and indica plants with other strains. In fact, cannabis plants defined as sativa or indica probably have little connection genetically to true sativa or indica strains. Whatever physical and cognitive advantages “pure” strains may have originally provided took a back seat long ago to the amazing benefits of terpenes.

The Best Terpenes for Creativity

The industry believes that the best terpenes for galvanizing creativity through the entourage effect are eucalyptol, D-limonene, TB-ocimene, A-bisabolol and B-myrcene.

While terpenes do not promote THC’s psychoactive effects, they do interact cogently with cannabinoids and with the brain’s dopamine and serotonin systems. Dopamine and serotonin are neurotransmitters that enhance concentration, focus and motivation–all factors involved in creative thinking.


A terpene with many proven medicinal qualities, eucalyptol has also been shown to increase blood flow throughout the brain and stimulate functioning of the frontal cortex. Although creativity is a whole-brain process, neurological studies investigating brain activity of individuals performing creative tasks indicate higher levels of frontal cortex activity. The frontal cortex is the main part of the brain associated with cognitive flexibility, abstraction and working memory.


Known for its anxiolytic and therapeutic properties, D-limonene may also boost creative thinking by making you feel relaxed and less susceptible to inhibited thinking. Perhaps the biggest obstacle to immersing yourself in a highly creative state is the fear that what you create will disappoint you and others. This kind of self-defeating talk can stop many of us from even writing that first sentence or brushing that first stroke on a blank canvas. The best terpenes for creativity like D-limonene and eucalyptol interact with other terpenes and cannabinoids to give you a sense of calm and lower inhibitions essential to exploring your limitless imagination.

TB-ocimene and A-bisabolol

Two lesser known cannabis terpenes that may help promote relaxation and calmness, TB-ocimene and A-bisabolol are said to enhance creativity and motivation by boosting the synergy among other terpenes involved in the entourage effect. When searching for the perfect cannabis product to expand your imagination, consider purchasing one that contains TB-ocimene and A-bisabolol.


Neurological imaging scans of individuals using cannabis enhanced with terpenes found that B-myrcene plays a leading role in synergizing terpenes and cannabinoids to produce the entourage effect. In fact, B-myrcene increases cell membrane permeability to accelerate the transport of CBD and THC over the blood-brain barrier and into the brain.

What Should You Look For in a Cannabis Product for Creativity?

To fully utilize the entourage effect, you need a product containing measured amounts of THC, CBD and terpenes. While cannabis strain doesn’t really matter when you want to feel inspired, it does matter if the cannabis product is made of discriminating levels of THC, CBD and, more importantly, terpenes.

Indulging your creative side is also a great way to support your physical and mental health. When someone is creating something–whether it’s a short story, a clay sculpture, a sandcastle or a pencil sketch of their pet–they enter a serene yet euphoric state of consciousness. Creative types report losing track of time, not hearing people speaking to them and even forgetting where they are. This altered state of mind not only reduces stress levels but leaves you feeling energized and joyful.

Create Cordial is a superior cannabis product providing the perfect balance of terpenes, THC, CBD and other cannabinoids to jumpstart your creativity. Create Cordial is precisely dosed, tastes delicious and is convenient to use. When you want to channel your inner muse, stimulate all five senses and ignite your imagination, pop a single-dose Create cordial to inspire the artist in you!


  1. https://www.cell.com/current-biology/pdf/S0960-9822(19)31379-X.pdf
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/
  3. https://www.karger.com/Article/FullText/509733
  4. https://www.nature.com/articles/s41598-020-61045-8#ref-CR18
  5. https://www.researchgate.net/publication/235659815
  6. https://cvdvt.org/terpene-of-the-month-bisabolol/
  7. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/myrcene
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804629/

Reviewed for scientific accuracy by Skyler Quisenberry.